<Suppliers Price>

NR1H4 activator 1

Names

[ CAS No. ]:
2242855-68-9

[ Name ]:
NR1H4 activator 1

Biological Activity

[Description]:

NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR
Research Areas >> Inflammation/Immunology

[Target]

EC50: 1 nM (Famesoid X Receptor)[1]


[In Vitro]

NR1H4 activator 1 exhibits a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. This assay is aim to determinate the ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR[1].

[References]

[1]. Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H53NO7S

[ Molecular Weight ]:
619.85

Related Compounds