2-naphthyl isocyanate
Names
[ CAS No. ]:
2243-54-1
[ Name ]:
2-naphthyl isocyanate
[Synonym ]:
2-naphthyl isocyanate
MFCD00014319
NAPHTHALENE,2-ISOCYANATO
EINECS 218-815-7
Chemical & Physical Properties
[ Density]:
1.09g/cm3
[ Boiling Point ]:
83 °C0.2 mm Hg(lit.)
[ Melting Point ]:
53-56 °C(lit.)
[ Molecular Formula ]:
C11H7NO
[ Molecular Weight ]:
169.17900
[ Flash Point ]:
102.1ºC
[ Exact Mass ]:
169.05300
[ PSA ]:
29.43000
[ LogP ]:
2.80710
[ Vapour Pressure ]:
0.00393mmHg at 25°C
[ Index of Refraction ]:
1.588
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ7950000
- CHEMICAL NAME :
- Naphthalene, 2-isocyanato-
- CAS REGISTRY NUMBER :
- 2243-54-1
- BEILSTEIN REFERENCE NO. :
- 0775794
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C11-H7-N-O
- MOLECULAR WEIGHT :
- 169.19
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 200 umol/L/3H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,81,1981
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
26-27-36/37/39-45
[ RIDADR ]:
UN 1994 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
QJ7950000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1
[ HS Code ]:
2929109000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2929109000
[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Nat. Commun. 5 , 5772, (2014)
The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple me...
Oxidative conversion by rat liver microsomes of 2-naphthyl isothiocyanate to 2-naphthyl isocyanate, a genotoxicant.Chem. Res. Toxicol. 5(6) , 791-6, (1992)
The present study investigated the oxidative metabolism of 2-naphthyl isothiocyanate catalyzed by rat liver microsomes. Incubation of 2-naphthyl isothiocyanate, microsomes, and NADPH yielded either N,...
Characterization and genotoxicity of DNA adducts caused by 2-naphthyl isocyanate.Carcinogenesis 11(11) , 2009-14, (1990)
Calf thymus DNA and M13mp9 RF DNA were modified with [ring-3H]2-naphthyl isocyanate (NIC) and analyzed by reverse-phase HPLC following enzymatic hydrolysis. In each case, essentially, a single radioac...