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ZXH 3-26

Names

[ CAS No. ]:
2243076-67-5

[ Name ]:
ZXH 3-26

Biological Activity

[Description]:

ZXH-3-26 is a selective BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4:5 nM (DC50, 5 hours of treatment)


[In Vitro]

ZXH-3-26 represents the first small molecule to allow pharmacologic targeting of BRD4 without significant inhibition or degradation of BRD2/3[1].

[References]

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H37ClN8O7S

[ Molecular Weight ]:
785.27

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds