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BAY 293

Names

[ CAS No. ]:
2244904-70-7

[ Name ]:
BAY 293

Biological Activity

[Description]:

BAY-293 is a potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction with an IC50 of 21 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 21 nM (KRAS-SOS1 interaction)[1]

[References]

[1]. Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₈N₄O₂S

[ Molecular Weight ]:
448.58

Related Compounds