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SOS1 activator 1

Names

[ CAS No. ]:
2245237-53-8

[ Name ]:
SOS1 activator 1

Biological Activity

[Description]:

SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Timothy R Hodges, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H32ClFN6

[ Molecular Weight ]:
483.02

Related Compounds