MAC glucuronide α-hydroxy lactone-linked SN-38

Names

[ Name ]:
MAC glucuronide α-hydroxy lactone-linked SN-38

Biological Activity

[Description]:

Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[References]

[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₅₄N₆O₂₀S

[ Molecular Weight ]:
1091.06

MAC glucuronide α-hydroxy lactone-linked SN-38

Names

Biological Activity

Chemical & Physical Properties

Related Compounds