WS-383 hydrochloride

Names

[ Name ]:
WS-383 hydrochloride

Biological Activity

[Description]:

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 11 nM (DCN1-UBC12 interaction)[1]

[References]

[1]. Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₁Cl₂N₉S₂

[ Molecular Weight ]:
498.46

WS-383 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds