MB 0223
Names
[ CAS No. ]:
2247732-89-2
[ Name ]:
MB 0223
Biological Activity
[Description]:
MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].
[Related Catalog]:
[Target]
IC50: 1.3 μM (Drp1)[1]
[In Vitro]
MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1]. MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H27N5OS
[ Molecular Weight ]:
457.59