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TDP1 Inhibitor-1

Names

[ CAS No. ]:
2248702-80-7

[ Name ]:
TDP1 Inhibitor-1

Biological Activity

[Description]:

TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 7 μM (Tyrosyl-DNA Phosphodiesterase 1)[1]

[References]

[1]. Zhang XR, et al. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. J Med Chem. 2018 Nov 21;61(22):9908-9930.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₆N₂O₅

[ Molecular Weight ]:
446.50

Related Compounds