MD2-TLR4-IN-1

Names

[ Name ]:
MD2-TLR4-IN-1

[Synonym ]:
MFCD32067977

Biological Activity

[Description]:

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

MD2-TLR4[1].

[References]

[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₄Cl₂N₄O

[ Molecular Weight ]:
421.28

Safety Information

[ Hazard Codes ]:
Xi

MD2-TLR4-IN-1

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds