Keap1-Nrf2-IN-12

Names

[ CAS No. ]:
2250082-04-1

[ Name ]:
Keap1-Nrf2-IN-12

Biological Activity

[Description]:

Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[Target]

IC50: 2.30 µM (Keap1-Nrf2)[1].


[In Vitro]

Keap1-Nrf2-IN-12 (compound 9a) shows metabolic stability in human liver microsomes with slight changes (97.7% remained) after 90 min of incubation[1].

[References]

[1]. Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28N2O10S2

[ Molecular Weight ]:
592.64

Related Compounds