JTP-117968

Names

[ CAS No. ]:
2250132-99-9

[ Name ]:
JTP-117968

Biological Activity

[Description]:

JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC50 of 6.8 nM), exhibits improved transrepression/transactivation dissociation[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

JTP-117968 has partial TR activity, but exhibits extremely low TA activity[1].

[References]

[1]. Takafumi Kurimoto, et al. JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation. Eur J Pharmacol. 2017 May 15;803:179-186.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H31F3N2O2

[ Molecular Weight ]:
520.59

Related Compounds