Tricarbonyldichlororuthenium(II) dimer

Names

[ Name ]:
Tricarbonyldichlororuthenium(II) dimer

[Synonym ]:
MFCD00011528
corm-2

Biological Activity

[Description]:

Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208.

Chemical & Physical Properties

[ Melting Point ]:
208ºC (dec.)

[ Molecular Formula ]:
C₆Cl₄O₆Ru₂

[ Molecular Weight ]:
512.01300

[ Exact Mass ]:
511.65400

[ LogP ]:
1.51000

[ Appearance of Characters ]:
crystal | off-white

[ Water Solubility ]:
Insoluble in water

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN3466

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Preparation

Articles

The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.

Br. J. Pharmacol. 171(12) , 2993-3009, (2014)

Infection with Gram-negative bacteria has been recognized as an initiator of rheumatoid arthritis, which is characterized by chronic inflammation and infiltration of immune cells. Carbon monoxide (CO)...

Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.

Int. J. Mol. Sci. 15(10) , 17974-99, (2014)

Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injur...

Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels.

J. Biol. Chem. 289(52) , 36150-7, (2014)

Hemichannels (HCs) are hexamers of connexins that can form gap-junction channels at points of cell contacts or "free HCs" at non-contacting regions. HCs are involved in paracrine and autocrine cell si...