CBP/p300-IN-17

Names

[ CAS No. ]:
2259640-87-2

[ Name ]:
CBP/p300-IN-17

Biological Activity

[Description]:

CBP/p300-IN-17 (compound 7) is a potent EP300/CBP HAT inhibitor with IC50s of 0.18, 0.69 µM for HAT EP300 and LK2 H3K27, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

EP300:0.18 μM (IC50)

LK2 H3K27:0.69 μM (IC50)

[References]

[1]. Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₈N₄O₃

[ Molecular Weight ]:
432.51

Related Compounds