Etanidazole

Names

[ Name ]:
Etanidazole

[Synonym ]:
Etanidazol
Ethanidazole
Etanidazole
1H-Imidazole-1-acetamide,N-(2-hydroxyethyl)-2-nitro
N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide
UNII:30DKA3Q1HL
N-(2-hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide
1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
Etanidazol [Spanish]
N-(2-hydroxyethyl)-2-nitroimidazole-1-acetamide
1-{N-(2-hydroxyethyl)-acetamido}-2-nitroimidazole
N-(2-Hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
Radinyl
SR-2508
Etanidazolum

Biological Activity

[Description]:

Etanidazole (SR 2508), a 2-nitroimidazole compound, is a hypoxic radiosensitizer used in cancer diagnosis and chemotherapy research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Marcus KJ, et al. A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1182-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
354.3°C (rough estimate)

[ Melting Point ]:
162-163° (Beaman); mp 164.5-165° (Lee)

[ Molecular Formula ]:
C₇H₁₀N₄O₄

[ Molecular Weight ]:
214.179

[ Exact Mass ]:
214.070206

[ PSA ]:
112.97000

[ LogP ]:
-1.66

[ Index of Refraction ]:
1.646

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3355000

CHEMICAL NAME :: Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-

CAS REGISTRY NUMBER :: 22668-01-5

BEILSTEIN REFERENCE NO. :: 0919296

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H10-N4-O4

MOLECULAR WEIGHT :: 214.21

WISWESSER LINE NOTATION :: T5N CNJ A1VM2Q BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3716 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 1 mmol/L/3D (Continuous)

REFERENCE :: 45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W., ed., New York, Masson Pub. USA, Inc., 1980 Volume(issue)/page/year: -,146,1980

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

[ RTECS ]:
NI3355000

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%