3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID

Names

[ Name ]:
3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID

[Synonym ]:
hip-a

Biological Activity

[Description]:

(±)-HIP-A is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM). (±)-HIP-A is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-A can be used in the study of neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2

Research Areas >> Neurological Disease

[References]

[1]. Andrea Pinto, et al. Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₈N₂O₄

[ Molecular Weight ]:
172.14

[ Exact Mass ]:
172.04800

[ PSA ]:
91.15000