dl-3-hydroxynorvaline

Names

[ Name ]:
dl-3-hydroxynorvaline

[Synonym ]:
2-Amino-3-hydroxy-valeriansaeure
2-amino-3-hydroxypentanoic acid
3-Hydroxynorvaline
2-Amino-3-hydroxymethylpyrazin
DL-3-Hydroxynorvaline
2-amino-3-hydroxy-valeric acid

Biological Activity

[Description]:

DL-3-Hydroxynorvaline is a valine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.237g/cm3

[ Boiling Point ]:
328.4ºC at 760mmHg

[ Melting Point ]:
231.2℃

[ Molecular Formula ]:
C₅H₁₁NO₃

[ Molecular Weight ]:
133.14600

[ Flash Point ]:
152.4ºC

[ Exact Mass ]:
133.07400

[ PSA ]:
83.55000

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum.

J. Biol. Chem. 265 , 14566-14571, (1990)

The amino acid analogs canavanine, 3-hydroxynorvaline, thialysine, 6-fluorotryptophan, m-fluorotyrosine, and 2-fluorophenylalanine were incorporated into proteins, synthesized in pig intestinal mucosa...

The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells.

J. Steroid Biochem. Mol. Biol. 46(3) , 337-47, (1993)

In the present study we have used several non-phosphorylatable analogs of the amino acids threonine and serine to determine the role of phosphorylation in the acute regulation of steroidogenesis in MA...

Inhibition of steroidogenesis in rat adrenal cortex cells by a threonine analogue.

J. Steroid Biochem. Mol. Biol. 40(1-3) , 421-9, (1991)

We have investigated the ability of amino acid analogues of serine and threonine to inhibit the increase in steroidogenesis elicited by addition of ACTH or cAMP in cells isolated from the rat adrenal ...