CR 665

Names

[ CAS No. ]:
228546-92-7

[ Name ]:
CR 665

[Synonym ]:
UNII-3BX9UG06GG
D-Argininamide,D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)
CR665

Biological Activity

[Description]:

CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

C50: 10.9 nM (κ-opioid)[1]


[In Vitro]

CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1]. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C36H49N9O4

[ Molecular Weight ]:
671.83200

[ Exact Mass ]:
671.39100

[ PSA ]:
231.17000

[ LogP ]:
6.67080

Related Compounds