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Apelin-12

Names

[ CAS No. ]:
229961-08-4

[ Name ]:
Apelin-12

[Synonym ]:
Apelin-12 (huMan,bovine,Mouse,rat) (Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat)
APELIN PRECURSOR (66-77) (HUMAN,BOVINE,MOUSE,RAT)
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
APELIN 12
(DES-GLN1)-APELIN-13 (HUMAN,BOVINE,MOUSE,RAT)
(Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat)
RPRLSHKGPMPF
APELIN-12 (HUMAN,BOVINE,MOUSE,RAT)
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
PREPROAPELIN (66-77) (HUMAN,BOVINE,MOUSE,RAT)

Biological Activity

[Description]:

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1]. Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2]. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4].

[References]

[1]. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203.

[2]. Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250.

[3]. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895.

[4]. Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78.

Chemical & Physical Properties

[ Molecular Formula ]:
C64H103N21O14S

[ Molecular Weight ]:
1422.70000

[ Exact Mass ]:
1421.77000

[ PSA ]:
581.08000

[ LogP ]:
2.26000

[ Storage condition ]:
-20°C

Related Compounds