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(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone

Names

[ CAS No. ]:
23027-91-0

[ Name ]:
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone

[Synonym ]:
Physalin A

Biological Activity

[Description]:

Physalin A is a withanolide isolated from Physalis alkekengi var. franchetii. Physalin A induces apoptosis associated with up-regulation of caspase-3 and caspase-8 expression. Physalin A induces autophagy, found to antagonize apoptosis in HT1080 cells. Physalin A has the potential for the research of cancer disease[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. He H, et al. Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. J Nat Prod. 2013;76(5):880-888.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H30O10

[ Molecular Weight ]:
526.53200

[ Exact Mass ]:
526.18400

[ PSA ]:
156.66000

[ LogP ]:
0.42990

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds