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5,7,8-Trimethoxyflavone

Names

[ CAS No. ]:
23050-38-6

[ Name ]:
5,7,8-Trimethoxyflavone

Biological Activity

[Description]:

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether; 8, 16, 32, 64 μM; for 24 hours) decreases NO production in a dose-dependent manner in RAW 264.7 macrophages. 5,7,8-Trimethoxyflavone does not change lipopolysaccharide (LPS)-induced (100 ng/mL) cell viability[1].

[References]

[1]. De-Yang Shen, et al. Chemical constituents from Andrographis echioides and their anti-inflammatory activity. Int J Mol Sci. 2012 Dec 27;14(1):496-514.

Chemical & Physical Properties

[ Density]:
1.242±0.06 g/cm3 at 760 mmHg

[ Boiling Point ]:
507.4±50.0 °C at 760 mmHg

[ Melting Point ]:
167-168 °C

[ Molecular Formula ]:
C18H16O5

[ Molecular Weight ]:
312.32

[ Storage condition ]:
2-8°C

Related Compounds