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FGFR1/DDR2 inhibitor 1

Names

[ CAS No. ]:
2308497-58-5

[ Name ]:
FGFR1/DDR2 inhibitor 1

Biological Activity

[Description]:

FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

IC50: 31.1 nM (FGFR1), 108.4 nM (KG-1), 3.2 nM (DDR2)[1].


[References]

[1]. Wang Q, et al. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H22F3N5O

[ Molecular Weight ]:
501.50

Related Compounds