Vincosamide

Names

[ Name ]:
Vincosamide

[Synonym ]:
(3β,15β,16α,17β)-21-Oxo-16-vinyl-19,20-didehydro-18-oxayohimban-17-yl β-D-glucopyranoside
(15β,16α,17β)-16-ethenyl-21-oxo-19,20-didehydro-18-oxayohimban-17-yl β-D-glucopyranoside
(15β,16α,17β)-21-Oxo-16-vinyl-19,20-didehydro-18-oxayohimban-17-yl β-D-glucopyranoside
Vincosamide
Oxayohimban-21-one, 19,20-didehydro-16-ethenyl-17-(β-D-glucopyranosyloxy)-, (3β,15β,16α,17β)-
Strictosamide
strictosamine
vincoside lactam
Oxayohimban-21-one, 19,20-didehydro-16-ethenyl-17-(β-D-glucopyranosyloxy)-, (15β,16α,17β)-

Biological Activity

[Description]:

Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Formagio ASN, et al. Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity. Inflammation. 2019 Oct;42(5):1561-1574. https://www.ncbi.nlm.nih.gov/pubmed/31102122 Formagio ASN, et al. Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity. Inflammation. 2019 Oct;42(5):1561-1574.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
816.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₀N₂O₈

[ Molecular Weight ]:
498.525

[ Flash Point ]:
447.4±34.3 °C

[ Exact Mass ]:
498.200226

[ PSA ]:
144.71000

[ LogP ]:
-0.55

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.716

[ Storage condition ]:
?20°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Articles

Simultaneous determination of six alkaloid components in rat plasma and its application to pharmacokinetic study of Danmu preparations by an ultra fast liquid chromatography-electrospray ionization-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 10-7, (2015)

Danmu injection and Danmu tablet are two widely used traditional Chinese medicine made of Nauclea officinalis (commonly known as Danmu), in which the alkaloids are the major active substances. In this...