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Apovincaminol

Names

[ CAS No. ]:
23173-26-4

[ Name ]:
Apovincaminol

[Synonym ]:
((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthen-10-yl)-methanol

Biological Activity

[Description]:

Vin-C01 is a potent pancreatic β-cells protective agent with an EC50 of 0.22 µM. Vin-C01 effectively promotes β-cell survival and protects β-cells from STZ-induced apoptosis. Vin-C01 can be used for type 2 diabetes mellitus research[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cardiovascular Disease

[Target]

EC50: 0.22 µM (pancreatic β-cells)[1]


[References]

[1]. Wang J, et al. Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2020 Feb 15;188:111976.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N2O

[ Molecular Weight ]:
308.42

[ Exact Mass ]:
308.18900

[ PSA ]:
28.40000

[ LogP ]:
3.51540

Related Compounds