Sodium thioctate

Names

[ Name ]:
Sodium thioctate

[Synonym ]:
Epakon
Sodium thioctate
Tioctene
Eparidasi
Thioctan
Tioctan
Tioicorzan
Tioctinessa
6,8-Thioctic acid sodium salt
Thioctic acid sodium salt

Biological Activity

[Description]:

α-Lipoic Acid sodium (Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium) is an antioxidant. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used for researching diabetes, neuropathy, obesity, abnormal pregnancy and other diseases[1][2][3][4][5].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Endocrinology

Research Areas >> Infection

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

NF-κB

HIV

Human Endogenous Metabolite

Microbial Metabolite

[References]

[1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.

[2]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.

[3]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.

[4]. Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139.

[5]. Salehi B, et al. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019 Aug 9;9(8):356.

Chemical & Physical Properties

[ Boiling Point ]:
362.5ºC at 760mmHg

[ Melting Point ]:
241-253 °C

[ Molecular Formula ]:
C₈H₁₃NaO₂S₂

[ Molecular Weight ]:
228.30700

[ Flash Point ]:
173ºC

[ Exact Mass ]:
228.02500

[ PSA ]:
90.73000

[ LogP ]:
1.45040

[ Vapour Pressure ]:
3.07E-06mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1185700

CHEMICAL NAME :: 1,2-Dithiolane-3-valeric acid, sodium salt

CAS REGISTRY NUMBER :: 2319-84-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H13-O2-S2.Na

MOLECULAR WEIGHT :: 228.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1138,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 197 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1138,1969

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%