8-Br-GTP

Names

[ Name ]:
8-Br-GTP

[Synonym ]:
8-Bromo-GTP
8-bromoguanosine triphosphate
8-bromoguanosine 5'-triphosphate

Biological Activity

[Description]:

8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%)[1][2].

[References]

[1]. Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84.

[2]. Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104.

Chemical & Physical Properties

[ Density]:
2.89g/cm3

[ Boiling Point ]:
1354.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅BrN₅O₁₄P₃

[ Molecular Weight ]:
602.07600

[ Flash Point ]:
772.8ºC

[ Exact Mass ]:
600.90100

[ PSA ]:
328.53000

[ Vapour Pressure ]:
0mmHg at 25°C

8-Br-GTP

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds