IV-23

Names

[ Name ]:
IV-23

Biological Activity

[Description]:

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC50 values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells[1]. IV-23 induces G2/M phase arrest[1].

[References]

[1]. Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₈BrNO₄

[ Molecular Weight ]:
392.24

IV-23

Names

Biological Activity

Chemical & Physical Properties

Related Compounds