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(S,R,S)-AHPC-C10-NH2 dihydrochloride

Names

[ CAS No. ]:
2341796-75-4

[ Name ]:
(S,R,S)-AHPC-C10-NH2 dihydrochloride

Biological Activity

[Description]:

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H53Cl2N5O4S

[ Molecular Weight ]:
686.78

[ Storage condition ]:
2-8°C

Related Compounds