Propargyl-Tos

Names

[ Name ]:
Propargyl-Tos

[Synonym ]:
3-Butyn-1-ol, 4-methylbenzenesulfonate
p-Toluenesulfonic Acid 3-Butynyl Ester
homopropargyl alcohol tosylate
4-tosyloxy-1-butyne
3-butynyl p-tosylate
but-3-yn-1-yl tosylate
3-Butyn-1-yl 4-methylbenzenesulfonate
3-Butynyl Tosylate
but-3-yn-1-yl p-toluenesulfonate
3-(1-Butynyl)-4-toluenesulphonate
But-3-yn-1-yl 4-methylbenzenesulfonate
3-Butynyl 4-methylbenzenesulfonate
3-Butynyl p-toluenesulfonate
MFCD00041687

Biological Activity

[Description]:

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
352.0±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₂O₃S

[ Molecular Weight ]:
224.276

[ Flash Point ]:
166.7±23.2 °C

[ Exact Mass ]:
224.050720

[ PSA ]:
51.75000

[ LogP ]:
2.01

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.535

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2905290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Preparation

Customs

[ HS Code ]: 2905290000

[ Summary ]:
2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.

J. Med. Chem. 39(16) , 3179-87, (1996)

A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure-activity relationships of this series were studied by synthesis of analo...

A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines.

Bioorg. Med. Chem. Lett. 13(13) , 2131-5, (2003)

The synthesis and biological evaluation of novel cycloheptaquinoline antagonists of the human H(3) receptor are described. Two series of compounds, bearing either an amino substituent or an alkyne lin...

Synthesis of Antitumor Lycorines by Intramolecular Diels-Alder Reaction.

J. Org. Chem. 61(5) , 1650-1654, (1996)

Pharmacologically interesting lycorines were obtained by a short, efficient method based on an intramolecular Diels-Alder reaction between an alpha-pyrone and an alkyne, followed by loss of CO(2) in a...