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Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Names

[ CAS No. ]:
2341841-02-7

[ Name ]:
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Biological Activity

[Description]:

Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[References]

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020;187:111952.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19ClN4O6

[ Molecular Weight ]:
410.81

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds