Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Names

[ Name ]:
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Biological Activity

[Description]:

Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020;187:111952.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₉ClN₄O₆

[ Molecular Weight ]:
410.81

Safety Information

[ Hazard Codes ]:
Xi