Pomalidomide-amido-C1-Br
Names
[ CAS No. ]:
2351106-38-0
[ Name ]:
Pomalidomide-amido-C1-Br
Biological Activity
[Description]:
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1].
[Related Catalog]:
[Target]
Cereblon
[In Vitro]
Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H12BrN3O5
[ Molecular Weight ]:
394.18
[ Storage condition ]:
2-8°C