1-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl)-1H-pyrrole-2,5-dione

Names

[ CAS No. ]:
2353409-63-7

[ Name ]:
1-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl)-1H-pyrrole-2,5-dione

[Synonym ]:
MFCD31811461

Biological Activity

[Description]:

Mal-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₅NO₁₀

[ Molecular Weight ]:
449.49

1-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl)-1H-pyrrole-2,5-dione

Names

Biological Activity

Chemical & Physical Properties

Related Compounds