DBCO-PEG6-amine,DBCO-PEG6-NH2

Names

[ CAS No. ]:
2353409-98-8

[ Name ]:
DBCO-PEG6-amine,DBCO-PEG6-NH2

Biological Activity

[Description]:

DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.22±0.1 g/cm3(Predicted)

[ Boiling Point ]:
823.0±65.0 °C(Predicted)

[ Molecular Formula ]:
C₃₃H₄₅N₃O₈

[ Molecular Weight ]:
611.73