Kallikrein 5-IN-2

Names

[ CAS No. ]:
2361160-57-6

[ Name ]:
Kallikrein 5-IN-2

Biological Activity

[Description]:

Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC50=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

Kallikrein 5[1]


[References]

[1]. Walker AL, et al. Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1454-1458.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H22N6O

[ Molecular Weight ]:
398.46

Related Compounds