Nardosinone

Names

[ Name ]:
Nardosinone

[Synonym ]:
Nardosinone
5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one

Biological Activity

[Description]:

Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[1].

[References]

[1]. Li P, et al. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.Brain Res Dev Brain Res. 2003 Nov 12;145(2):177-83.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
330.2±32.0 °C at 760 mmHg

[ Melting Point ]:
108-110℃

[ Molecular Formula ]:
C₁₅H₂₂O₃

[ Molecular Weight ]:
250.333

[ Flash Point ]:
142.0±25.2 °C

[ Exact Mass ]:
250.156891

[ PSA ]:
35.53000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
2-8C

Safety Information

[ HS Code ]:
29145090

Nardosinone

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream