2-Propen-1-one,1,3-bis(4-methoxyphenyl)-

Names

[ Name ]:
2-Propen-1-one,1,3-bis(4-methoxyphenyl)-

[Synonym ]:
MFCD00025815
4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE
DIMETHOXYCHALCONE,4,4'-(RG)
4,4'-dimethoxy-chalcone
1,3-bis-{4-methoxy-phenyl}-propen-(1)-one-(3)
1,3-bis-(4-methoxyphenyl)-propenone
2-Propen-1-one,1,3-bis(4-methoxyphenyl)
1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
(E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
DIMETHOXYCHALCONE,4,4'
4,4'-Dimethoxy-chalkon

Biological Activity

[Description]:

4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Metabolic Disease

[Target]

Autophagy[1]

[In Vivo]

The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1]. 4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1]. Animal Model: 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1] Dosage: 100 mg/kg Administration: Injected intraperitoneally with a single Result: Triggered autophagic flux in the heart and liver.

[References]

[1]. Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651.

Chemical & Physical Properties

[ Density]:
1.128g/cm3

[ Boiling Point ]:
444.6ºC at 760 mmHg

[ Melting Point ]:
101°C

[ Molecular Formula ]:
C₁₇H₁₆O₃

[ Molecular Weight ]:
268.30700

[ Flash Point ]:
214.6ºC

[ Exact Mass ]:
268.11000

[ PSA ]:
35.53000

[ LogP ]:
3.59990

[ Vapour Pressure ]:
4.23E-08mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
N

[ Risk Phrases ]:
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .

[ Safety Phrases ]:
S61

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%