Dopamine D3 receptor ligand-4

Names

[ CAS No. ]:
2376333-77-4

[ Name ]:
Dopamine D3 receptor ligand-4

Biological Activity

[Description]:

Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D3 receptor ligand, with a Ki of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D3 over D2 (Ki=7.43 nM). Dopamine D3 receptor ligand-4 can be used for the research of Cocaine use disorder[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D3 Receptor:0.5 nM (Ki)

D2 Receptor:7.43 nM (Ki)


[References]

[1]. Blass BE, et al. Design, synthesis, and evaluation of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides as selective dopamine D3 receptor ligands. Med Chem Res 31, 132-145 (2022).

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28N4OS

[ Molecular Weight ]:
444.59

Related Compounds