PROTAC KRAS G12C degrader-2

Names

[ CAS No. ]:
2378257-72-6

[ Name ]:
PROTAC KRAS G12C degrader-2

Biological Activity

[Description]:

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Crew Andrew, et al. Preparation of bifunctional compounds as modulators of proteolysis useful for treating cancer. World Intellectual Property Organization, WO2019195609 A2. 2019-10-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C51H53ClFN9O7

[ Molecular Weight ]:
958.47

Related Compounds