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PROTAC K-Ras Degrader-1

Names

[ CAS No. ]:
2378258-52-5

[ Name ]:
PROTAC K-Ras Degrader-1

Biological Activity

[Description]:

PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

Signaling Pathways >> PROTAC >> PROTAC

[Target]

KRAS(G12C)

Cereblon

[References]

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₆₂N₁₀O₁₀

[ Molecular Weight ]:
999.12

[ Storage condition ]:
-20°C

Related Compounds