Gly-7-MAD-MDCPT

Names

[ CAS No. ]:
2378427-68-8

[ Name ]:
Gly-7-MAD-MDCPT

Biological Activity

[Description]:

Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to 786-0, BxPC3, HL-60 and SK-MEL-5 with IC50 values of 100-1000 nM[1]. Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to L540cy, MM.1R, M0LM13, Ramos, SK-MEL-5, SU-DHL-4 and U266 with IC50 values of 10-100 nM[1].

[References]

[1]. Jeffrey Scott, et al. Preparation of camptothecin peptide conjugates as antitumor agents. WO2019195665. 2019 10-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22N4O7

[ Molecular Weight ]:
478.45

Related Compounds