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CCT373566

Names

[ CAS No. ]:
2378853-66-6

[ Name ]:
CCT373566

Biological Activity

[Description]:

CCT373566 is a potent and orally active degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[References]

[1]. Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65(12):8191-8207.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H29ClF2N6O3

[ Molecular Weight ]:
547.00

Related Compounds