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Liensinine perchlorate

Names

[ CAS No. ]:
2385-63-9

[ Name ]:
Liensinine perchlorate

[Synonym ]:
Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-, perchlorate (1:1) (salt)
4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-{[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl]oxy}phenol perchlorate (1:1)

Biological Activity

[Description]:

Liensinine Perchlorate is a constituent of Nelumbo nucifera Gaertn, with ani-hypertension and anti-cancer activities. Liensinine Perchlorate induces colorectal cancer (CRC) cell apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

IC50: apoptosis[1]


[In Vitro]

Liensinine Perchlorate is found to induce apoptosis and exert a significant inhibitory effect on the proliferation and colony-forming ability of CRC cells in a dose-dependent manner without any observed cytotoxicity on normal colorectal epithelial cells[1].

[References]

[1]. Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

Chemical & Physical Properties

[ Molecular Formula ]:
C37H43ClN2O10

[ Molecular Weight ]:
711.198

[ Exact Mass ]:
710.260620

[ PSA ]:
155.30000

[ LogP ]:
6.49140

Related Compounds