TGFβ-IN-2

Names

[ CAS No. ]:
2387678-02-4

[ Name ]:
TGFβ-IN-2

Biological Activity

[Description]:

TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Research Areas >> Inflammation/Immunology

[References]

[1]. Dexin Deng, et al. Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis. Eur J Med Chem. 2020 Jan 1;185:111790.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22N2O4

[ Molecular Weight ]:
378.42

Related Compounds