HIF-IN-1

Names

[ CAS No. ]:
2393928-76-0

[ Name ]:
HIF-IN-1

Biological Activity

[Description]:

HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[References]

[1]. Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28(1):115207.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H12N2O

[ Molecular Weight ]:
260.29

Related Compounds