SK3 Channel-IN-1

Names

[ CAS No. ]:
2396571-04-1

[ Name ]:
SK3 Channel-IN-1

Biological Activity

[Description]:

SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 16 μM in CaCo-2[1]


[References]

[1]. Kouba S, et al. Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity. Eur J Med Chem. 2020;186:111854.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H49NO

[ Molecular Weight ]:
379.66

Related Compounds