GAK inhibitor 2

Names

[ CAS No. ]:
2396706-31-1

[ Name ]:
GAK inhibitor 2

Biological Activity

[Description]:

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.024 μM (GAK)[1]


[References]

[1]. Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28(1):115188.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23N3O3S

[ Molecular Weight ]:
385.48

Related Compounds