Anticancer agent 65

Names

[ CAS No. ]:
2407861-48-5

[ Name ]:
Anticancer agent 65

Biological Activity

[Description]:

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP

Bcl-2

Bax


[In Vitro]

Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1].

[References]

[1]. Ma L, Wang X, Li W, Miao D, Li Y, Lu J, Zhao Y. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H63NO5

[ Molecular Weight ]:
589.89

Related Compounds