hCAII-IN-2

Names

[ CAS No. ]:
2408599-78-8

[ Name ]:
hCAII-IN-2

Biological Activity

[Description]:

hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with Ki values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: 3.8 nM (hCA II), 19.6 nM (hCA IX), 45.2 nM (hCA XII), 261.4 nM (hCA I)[1]


[References]

[1]. Khalil OM, et al. Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases. Eur J Med Chem. 2020 Feb 15;188:112021.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H18ClN5O4S

[ Molecular Weight ]:
519.96

Related Compounds