STING agonist-22

Names

[ Name ]:
STING agonist-22

Biological Activity

[Description]:

STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING agonist-22 (CF501) 导致 THP-1 细胞中先天免疫反应的快速和强烈激活[1]。

[In Vivo]

STING agonist-22 (CF501) 以可接受的安全性在小鼠中稳健但短暂地激活先天免疫[1]。 Animal Model: Balb/c mice (female, six weeks old)[1] Dosage: 20, 75 μg Administration: Intramuscular injection Result: Although innate immunity was activated only transiently by CF501, it should be sufficient to stimulate the required humoral and cellular immune responses. The half-life of CF501 was 0.5 h and there was no detectable CF501 in the plasma after 2 h of the injection.

[References]

[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₈N₁₄O₆

[ Molecular Weight ]:
820.90

STING agonist-22

Names

Biological Activity

Chemical & Physical Properties

Related Compounds