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PROTAC BRD4 Degrader-5

Names

[ CAS No. ]:
2409538-70-9

[ Name ]:
PROTAC BRD4 Degrader-5

Biological Activity

[Description]:

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4


[In Vitro]

PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1]. Western Blot Analysis[1] Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells Concentration: 5 nM, 10 nM, 50 nM, 100 nM Incubation Time: 4 hours Result: Degradation of BRD4 in MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cell.

[References]

[1]. Marı A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.

Chemical & Physical Properties

[ Molecular Formula ]:
C50H62ClN9O8S2

[ Molecular Weight ]:
1016.67

[ Storage condition ]:
2-8°C

Related Compounds